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KMID : 1188320210150020217
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Gut and Liver
2021 Volume.15 No. 2 p.217 ~ p.224
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A Comparative Study on Aqueous Chitosan Solution and Various Submucosal Injection Fluids Using a Three-Dimensional Sensor
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Jeon Han-Jo
Jeong Seung
Choi Hyuk-Soon
Jang Se-Hyun
Kim Sang-Hoon
Kim Seung-Han
Lee Jae-Min
Kim Eun-Sun
Keum Bo-Ra
Jeen Yoon-Tae
Lee Hong-Sik
Chun Hoon-Jai
Chung Jong-Hoon
Kim Seong-Nam
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Abstract
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Background/Aims: Chitosan, a natural polymer widely used in the biomaterials field, has been proposed as a potential submucosal injection solution. The purpose of this study was to compare the performance and efficacy of aqueous chitosan solution and commercialized submucosal injection fluids using a three-dimensional sensor and to evaluate the efficacy of the measured parameters.
Methods: Normal saline (0.9% NaCl), as a control, Eleview® (Poloxamer 188), Blue EyeTM (0.4% hyaluronic acid), and aqueous chitosan solution (2.0%) were injected into the submucosa of porcine stomachs ex vivo. The mucosal elevation height, elevated surface area, and angle of the tangent of the submucosal fluid cushion were measured using a three-dimensional sensor. The rates of change for each variable were calculated, and the correlation between parameters was analyzed. Tissue specimens were stained with hematoxylin and eosin.
Results: All variables exhibited the highest values under chitosan injection. The mucosal elevation height rate of change differed significantly between normal saline and chitosan solution (p=0.024). The elevated surface area rates of change for normal saline and Eleview® were significantly different from those for TS-905 and chitosan solution (p=0.006 and p=0.009, respectively). Further, height, area, and angle showed a positive correlation (p<0.001). A histological examination revealed an even distribution of aqueous chitosan within the submucosa without tissue damage.
Conclusions: Aqueous chitosan was superior to normal saline and Eleview® and was noninferior to TS-905. A three-dimensional sensor and the measured parameters were effective and useful for evaluating the performance of submucosal fluids.
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KEYWORD
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Endoscopy, gastrointestinal, Chitosan, Stomach, Injections, Imaging, three-dimensional
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